sh2 domain การใช้
- The kinase activity of Syk is regulated by the SH2 domains.
- The protein contains three SH3 domains and one SH2 domain.
- I just checked four first red links to human genes in SH2 domain.
- This allows SRC or SRC family kinase to bind NEDD9 via its SH2 domain.
- Upon phosphorylation, these tyrosines serve as docking domains for SH2 domains containing proteins.
- One family of nonreceptor TKs includes the genes SH2 domain upstream of the TK domain.
- The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain.
- These non-receptor cytoplasmic tyrosine kinases share a characteristic dual SH2 domain separated by a linker domain.
- SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain.
- V-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains.
- A large number of SH2 domain structures have been solved and many SH2 proteins have been knocked out in mice.
- SH2 domain recognizes the phosphorylated tyrosine residues ( pTyr ) on its substrate to activate a specific intracellular signaling pathway.
- Once activated, Fyn can bind to NR2B through its SH2 domain and mediate phosphorylation of its Tyr-1472 site.
- The recruitment of SH2 domain proteins to autophosphorylated RTKs at the plasma membrane is essential for initiating and propagating downstream signaling.
- The SH2 domains bind preferentially to phosphorylated tyrosine residues in the amino acid sequence context Y-X-X-M.
- The structure contains typical SH2 domain, with two ?-helices and three antiparallel ?-strands on each SH2 domain.
- The structure contains typical SH2 domain, with two ?-helices and three antiparallel ?-strands on each SH2 domain.
- He was also instrumental in understanding how the SH2 domain controls tyrosine kinase signaling by binding to phosphorylated tyrosines in activated receptors.
- Phosphotyrosine ( P . Tyr ) residues on activated RTKs are recognized by a phosphodependent-binding domain, the SH2 domain.
- Other graphics programs such as DeepView ( example : urease ) and MolMol ( example : SH2 domain ) also produce ribbon images.
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